Role Summary The C1 Fermentation Scientist (Methylotroph / Methanol Kinetics) drives biological performance and feeding strategy optimization. You will design, implement, and manage methanol-limited fed‑batch and continuous bioprocessing strategies for methylotrophic strains. Your core focus is building tight feedback loops to keep residual methanol at safe, sub‑toxic levels during high‑density fermentation (HCDC).
Key Responsibilities - Fed‑Batch & Continuous Fermentation Strategy: Design and execute methanol-limited fed‑batch and continuous fermentation strategies to prevent substrate inhibition and cellular toxicity.
- Feedback Loop Control: Build and optimize real‑time feedback loops utilizing online dissolved oxygen (DO) spikes, carbon dioxide evolution rates (CER), or mid‑infrared (MIR) sensors.
- Growth Kinetics: Characterize specific growth rates, substrate yield coefficients, and metabolic threshold...