The University Hospital Ulm and its employees stand for a modern and high quality patient care, excellent university research and medical education focused on the future as well as apprenticeships in attractive professional fields. The requirements for this are qualified and committed employees.



The role of DNA damage response in the development of pediatric myelodysplastic syndromes


Myelodysplastic syndromes (MDS) can be caused by predisposing germline mutations that result in clonal aberrations. The latter may increase the risk for the development of bone marrow failure, dysplasia, and malignant transformation. Since DNA damage occurs naturally in the process of hematopoietic differentiation, DNA damage response (DDR) plays a crucial role in protecting stem cell integrity.

In this research project we plan to investigate the DDR capacity of induced pluripotent stem cell (iPSC)-derived hematopoietic stem cells (HSCs) modeling pediatric MDS...