🌿 Back to all jobs

🥝 Post-doc Design and synthesis of Enzyme Inhibitors

VU Amsterdam | Amsterdam, Netherlands | Posted June 21, 2026

Job Description

Your function

Using your experience in small-molecule organic synthesis, you will design and synthesise new heterocyclic molecules that are able to inhibit PDE enzymes. You will synthesise, isolate and characterize novel drug-like molecules. Your compounds will be screened for enzyme inhibition, enabling the development of structure-activity relationships that guide the synthesis of additional compounds. 

The candidate will join a well-integrated, multidisciplinary team and work closely with colleagues who conduct Computer-Aided Drug Design (CADD) studies and biological screening. The results are expected to lead to publications in high-quality scientific journals, while also contributing to the specific goal of developing new medicines for Alzheimer’s disease.

Your profile

  • Experience with modern organic synthesis, including heterocyclic chemistry, parallel chemistry and a wide variety of reaction types.
  • Experience in p...
  • Apply for This Position

    Submit Application