About the role
We are seeking a collaborative and self‑motivated bioinformatician post‑doctoral fellow to work on extrachromosomal DNA (ecDNA) in a vibrant, highly collegiate environment. ecDNA are circular genomic structures that can drive ultra‑high copy number amplification and correlate with poor clinical outcomes. This project will analyse ecDNA evolution over time using single‑cell RNA/ATAC sequencing and develop a ctDNA‐based approach for detecting and monitoring ecDNA to support biomarker and treatment development. The research will utilise existing whole‑genome sequencing data from the TRACERx lung‑cancer evolution and PEACE research autopsy programmes, and will be part of the eDyNAmiC Cancer Grand Challenge.
The work will involve analysing large multi‑region matched primary and metastatic tumour datasets, developing computational pipelines for ecDNA detection...